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CLINICAL TRIAL  OF NATURAL LOCAL APPLICATION
, EFFECTS  IN A PROSPECTICAL STUDIED ON 280 PEOPLE

SUMMARY

The clinical checking took place in the surgeries of Milan and Rome (Italy) A group of people suffering from different kinds of Psoriasis have been examined. Those persons did the Natural Local Applications, of   products, testing the results after one month, two months, three months and six months. The aim of the test was checking the efficacy of such a therapy against psoriasis, a pathology which affects at least 100 millions of persons all over the world.

METHODS AND MATERIAL

The products, consist of three creams: , , (whose names and identification codes have been communicated to the Italian Ministry of Health in compliance with the European and American legislation in force). The creams are used according to precise directions and according to the location of the lesions. The tested group was composed by 140 women and 140 men, (age: from 18 to 70 years). This group was subdivided according to the cutaneous lesions caused by psoriasis. The creams were used according to the directions reported in the examples.

The group was tested within several periods, such as 1 month, 2 months, 3 months and 6 months. The group was subdivided in subgroups according to the location of lesions. A further subgroup was composed by those persons whose lesions were wider than 15 centimeters in diameter. For each period we have an evaluation in percentage

We photographed the subjects with a traditional camera (Canon EOS 3000 with a Canon objective 38-76 mm) with films and negatives. These photos and their negatives unequivocally witness the results achieved. The photos were taken at the beginning of the study and at its end.

 

LOCALIZATIONS OF LESIONS PERCENTAGE OF PEOPLE SUFFERING
Scalp 60%
elbows 72%
Hands 44%
Face 15%
Chest (Breast) 24%
Back 68%
Gluteus 48%
Abdomen 37%
Navel 26%
Thighs 16%
Knees 68%
Legs 27%
Feet 32%
Genital Region 46%
Hands Fingernails 28%
Feet Fingernails 64%

RESULTS

The results achieved, calculated in percentage, were examined in relation to the location of the psoriasis lesions. We did not give importance to the sex (male or female).

In the test were not included persons under 18 years, because they usually need an amazing short period for the “restitutio ad integrum” (reconstruction of a sound and normal skin). Such a rapidity could change the results of the test. In fact, the babies achieve a “restitutio ad integrum” in a very short time due to their metabolism’s speed.

The results achieved are supported by the photos, you will see some of them later on.

RESULTS OF AFTER ONE MONTH

LOCALIZATIONS OF LESIONS Total "Restitutio ad integrum"
 (100%)
Regression of 80% Regression of 50% Regression of 25% No Improvement
Scalp 80% 11% 8% 1% 0%
elbows 59% 15% 17% 9% 0%
Hands 60% 19% 15% 6% 0%
Face 87% 5% 8% 0% 0%
Chest (Breast) 44% 23% 21% 12% 0%
Back 51% 24% 19% 6% 0%
Gluteus 21% 11% 36% 32% 0%
Abdomen 24% 15% 42% 19% 0%
Navel 36% 33% 18% 13% 0%
Thighs 15% 16% 42% 27% 0%
Knees 38% 37%  21% 4% 0%
Legs 18% 22% 24% 36% 0%
Feet 38% 29% 21% 12% 0%
Genital Region 50% 32% 15% 3% 0%
Hands Fingernails 12% 25% 44% 19% 0%
Feet Fingernails 19% 18% 51% 12% 0%
Lesions with a diameter  superior at 15 cm. 7% 58%

35%

0%

 

RESULTS OF AFTER TWO MONTHS

LOCALIZATIONS OF LESIONS Total "Restitutio ad integrum"
 (100%)
Regression of 80% Regression of 50% Regression of 25% No Improvement
Scalp 90% 10% 0% 0% 0%
elbows 85% 11% 4% 0% 0%
Hands 88% 12% 0% 0% 0%
Face 98% 2% 0% 0% 0%
Chest (Breast) 70% 24% 6% 0% 0%
Back 69% 25% 6% 0% 0%
Gluteus 55% 42% 3% 0% 0%
Abdomen 72% 24% 4% 0% 0%
Navel 85% 15% 0% 0% 0%
Thighs 63% 24% 13% 0% 0%
Knees 92% 7% 1% 0% 0%
Legs 54% 30% 16% 0% 0%
Feet 81% 14% 5% 0% 0%
Genital Region 91% 8% 0% 0% 0%
Hands Fingernails 35% 36% 19% 10% 0%
Feet Fingernails 42% 28% 30% 0% 0%
Lesions with a diameter  superior at 15 cm. 65% 28% 7%

0%

0%

 

RESULTS OF AFTER THREE MONTHS

LOCALIZATIONS OF LESIONS Total "Restitutio ad integrum"
 (100%)
Regression of 80% Regression of 50% Regression of 25% No Improvement
Scalp 100% 0% 0% 0% 0%
elbows 100% 0% 0% 0% 0%
Hands 100% 0% 0% 0% 0%
Face 100% 0% 0% 0% 0%
Chest (Breast) 100% 0% 0% 0% 0%
Back 100% 0% 0% 0% 0%
Gluteus 100% 0% 0% 0% 0%
Abdomen 100% 0% 0% 0% 0%
Navel 100% 0% 0% 0% 0%
Thighs 100% 0% 0% 0% 0%
Knees 100% 0% 0% 0% 0%
Legs 100% 0% 0% 0% 0%
Feet 100% 0% 0% 0% 0%
Genital Region 100% 0% 0% 0% 0%
Hands Fingernails 70% 21% 9% 0% 0%
Feet Fingernails 80% 12% 8% 0% 0%
Lesions with a diameter  superior at 15 cm. 96% 4% 0%

0%

0%

 

RESULTS OF AFTER SIX MONHTS

LOCALIZATIONS OF LESIONS Total "Restitutio ad integrum"
 (100%)
Regression of 80% Regression of 50% Regression of 25% No Improvement
Scalp 100% 0% 0% 0% 0%
elbows 100% 0% 0% 0% 0%
Hands 100% 0% 0% 0% 0%
Face 100% 0% 0% 0% 0%
Chest (Breast) 100% 0% 0% 0% 0%
Back 100% 0% 0% 0% 0%
Gluteus 100% 0% 0% 0% 0%
Abdomen 100% 0% 0% 0% 0%
Navel 100% 0% 0% 0% 0%
Thighs 100% 0% 0% 0% 0%
Knees 100% 0% 0% 0% 0%
Legs 100% 0% 0% 0% 0%
Feet 100% 0% 0% 0% 0%
Genital Region 100% 0% 0% 0% 0%
Hands Fingernails 75% 19% 6% 0% 0%
Feet Fingernails 91% 5% 4% 0% 0%
Lesions with a diameter  superior at 15 cm. 100% 0% 0%

0%

0%

A little number of patients, the 2%, didn’t finish the therapy, or didn’t execute it correctly. The reasons of such a behavior were personal. However, these persons were excluded from the final evaluation. This means that it is really important to follow scrupulously the directions in the instructions.

The patients reported that, just after the first uses, they noticed a remarkable decrease of the itch and/or the burning, typical of the lesions caused by Psoriasis. The disappearance of itch and/or burning, offers improves the quality of life and, above all, allows the disappearance of the scratch, helping the “restitutio ad integrum” of the skin.

The 3% of the tested subjects, noticed itches in the areas surrounding the lesions. But this trouble was solved by advising them of not using an old transparent plastic sheet, perhaps hold in the kitchen. In fact, the transparent sheets are in polyethylene and they can deteriorate in the presence of fats or oils. In every common kitchen, there are many vapors, containing fats. For this reason, it is really important to buy a new transparent plastic sheet, holding it out of the kitchen.

A small number of subject, the 4%, noticed a slight itch and/or burning on the treated lesions in different parts of the day. After a thorough analysis and a talk, we noticed that this moments coincided with the lack or the short quantity of . Once realizing that the use of must be steady and abundant, the itch and/or burning disappear.

We didn’t find remarkable collateral effects. If used according to directions the do not cause undesired effects

The 98% of patients was completely satisfied about times and results.

 

CONCLUSIONS

Noticing the results of this scientific test, it emerges how it is important the correctness in the therapy with the products. The  “restituito ad integrum” (reconstruction of a sound skin) is achieved nearly at 100% in those persons who succeed in finishing the therapy. Treatment times could vary according to the extent of the lesions and according to their location. As concerns nails, the therapy is a little bit longer, because nails usually are influenced by the general health conditions of the subjects.

With this project, carried out through the scientific research protocol, we noticed that the “restitutio ad integrum”, or reconstruction of a sound skin, occurs gradually, through different stages:

* After the first applications, the scales that covered the skin lesions will fall down
 
*

Eliminated the scales, the lesions will appear dark red
 

* In the following days, it is necessary to continue doing daily applications: the colour will become lighter and lighter. From dark red colour to pink colour
 
*

At this moment the skin is recovery; you will see only a pink colour. So it will be possible to do the applications less frequently (one day Yes and one day No). Anyway it would be important to check that everything is all right during the day without applications
 

*

We finally get the “Restitutio ad integrum”. So the skin will be completely recovered

We noticed in all the subjects a mental and social improvement, and obviously even an improvement in the general quality of life.

Studying the prospectical project (see below), we can suppose the lesions who are more sensitive at the natural local application method, they  are the ones that have the largest representation areas at cerebral level.

 

All photographs were taken with a traditional photographic camera (Canon EOS 3000, lens Canon 38-76 mm), that is with roll and negatives. These photos, with their negatives, testify the obtained results in an unequivocal way. The photos were taken both before of the beginning of the study, and at the end of the same

 

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Before After Before After
       
       
       
       
       
       
       
       
   
   
   
       
       
       

It is recalled that all photographs were taken with a traditional photographic camera and therefore with negatives

that testify their correctness
Photos negatives are kept demonstrating that the photos are true
Further testimony of scientific correctness with which the clinical Trial has been conducted

 

Dr. Enzo DI MAIO MD, Dra Renata Romera
 
 

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